VegetarianInBoston Maynard S. Clark's Veggie and Boston Blog talks about vegetarian topics AND Boston-related topics, often intersecting them interestingly. Maynard S. Clark is a long-time and well-known vegan in Greater Boston, who often quips in his 'elevator pitch': "I've been vegan now for over half my natural life, longer than most human earthlings have been alive."
Saturday, March 27, 2010
Do Fish Feel Pain?
“Tapped” - free April 1 screening hosted by Harvard Business School's Green Living Program
Film uncorks facts about the bottled water business
How Fish Feel Pain
Oxford University Press has just released Do Fish Feel Pain?, which can be purchased as a PDF through eBooks.com or as a physical book through online retailers.
Do Fish Feel Pain?
Braithwaite, Victoria
This multifaceted book explores recent scientific research of whether or not fish can experience pain but also explores human behavior in our relationship to and perception of fish.
We can no longer overlook mounting evidence that fish feel pain and suffer. To avoid eating mammalian flesh for ethical or moral reasons grounded in currently available evidence (that they suffer) requires including fish because evidence now shows that they, too, suffer violence because of their neurological capacities to organize sensation in complex bundles.
Wednesday, March 24, 2010
Test-of-Concept Trials
What is a test of concept trial?
The number of volunteers required for such trials is smaller, only around 2-5,000 volunteers as compared to over 10,000 for Phase III trials. Phase IIb trials are therefore much easier to design and manage, and are less costly. Since fewer doses of vaccine are required, these trials are also much faster to implement because the manufacturing process is limited. Very importantly, they may also provide researchers with the immune correlates of protection, or the immune response generated by the vaccine that cause it to be effective. This can often be difficult to do in large Phase III trials.
However because Phase IIb trials are run in smaller populations, the precision of the trial is less. Therefore a vaccine can not be licensed based on the results of Phase IIb testing. If the results of a Phase IIb trial indicate that this approach is promising, a Phase III efficacy trial will be required before licensing and use of the vaccine. This means that the decision to run a Phase IIb trial will extend the total amount of time it takes to complete the clinical trials process. Phase IIb trials are an important screening step for different vaccine candidates and help organizations determine which ones to move forward into Phase III trials, without expending more time and money.
The idea of using Phase IIb studies is more than a decade old but the first one involving an AIDS vaccine candidate began just last year. Test of concept trials have already been done for other vaccines as well as for other preventive technologies. US-based Merck and GlaxoSmithKline Biologicals in Europe tested their respective vaccine candidates for human papilloma virus in Phase IIb trials. These candidates are now both being tested in Phase III efficacy trials. The HIV Prevention Trials Network is also testing a microbicide candidate known as Buffergel PRO2000 in an ongoing Phase IIb trial to see if this agent can block transmission of HIV.
Because the challenge of developing an effective AIDS vaccine has proven so difficult and the need remains so great, researchers must evaluate several candidates as quickly as possible. This requires testing several candidates at the same time.
Researchers are also using new approaches to try to find an effective AIDS vaccine. Test of concept studies are one way to find out quickly if these new candidates can be successful. An example of this is the first Phase IIb trial of an AIDS vaccine candidate, which is being conducted by Merck and the HIV Vaccine Trials Network. This ongoing study is testing the company's lead vaccine candidate known as MRKAd5 in approximately 3,000 volunteers. The MRKAd5 candidate primarily generates a cellular immune response, but scientists are unsure if this type of vaccine will be sufficient to protect people from HIV infection. Merck decided to test this type of vaccine in a Phase IIb trial to find out if this strategy will be able to prevent HIV infection or to slow the progression of disease in people who do become infected through exposure in their community. The results of this trial will influence the company's decision to go ahead with a Phase III trial and will provide the entire AIDS vaccine field with critical information about the importance of cell-mediated immune responses in vaccine efficacy.
Another advantage of a Phase IIb trial is that it allows researchers to evaluate a candidate in a more confined study population. The MRKAd5 candidate is based on a particular strain of a human virus that naturally causes the common cold (adenovirus serotype 5). This candidate may not work as well in people who have already developed immunity to this strain of natural adenovirus, due to what is called pre-existing immunity (see February Primer on Understanding Pre-existing Immunity). Initially Merck's Phase IIb trial was designed to include only people who had low levels of pre-existing immunity, so that they could find out if the vaccine concept was even feasible under optimal conditions. The trial has since been amended to include a more diverse population of volunteers.
Tuesday, March 23, 2010
Monday, March 22, 2010
Tanzania's Attempt to Allow Sale of Elephant Ivory Fails
Attempt to Allow Sale of Elephant Ivory Fails
Tanzania had petitioned the Convention on International Trade in Endangered Species, which is now meeting in Doha, Qatar, to allow a one-time sale of ivory. The proposal had been strongly opposed by scientists. On Monday, in a rare victory for science-based conservation at this meeting, the organization's members voted to reject the plan.
Saturday, March 20, 2010
Itching ears
Wikisource has original text related to this article: |
- 2 Timothy 4:3-4: For the time will come when they will not endure sound doctrine; but after their own lusts shall they heap to themselves teachers, having itching ears; And they shall turn away their ears from the truth, and shall be turned unto fables. (KJV)
Thursday, March 18, 2010
The Case Against Test Tube Meat
The Case Against Test Tube Meat
.I can say that as a vegetarian of 43 years' standing that any vegetarian who objects to [cloning and lab-growing meat cells] because it would still have been "seeded" from a living animal will have lost sight entirely of the moral reason for vegetarianism in the first place - not to do needless harm to feeling creatures.[19]
[1] | "Scientists Grow Meat In A Laboratory," August 11, 2005,TheBostonChannel.com, WCVB-TV,http://www.thebostonchannel.com/health/4838281/detail.html |
[2] | "When meat is not murder," Ian Sample, Saturday August 13, 2005, The Guardian, http://www.guardian.co.uk/genes/article/0,,1548451,00.html |
[3] | "Scientists aim for lab-grown meat," August 15, 2005, Sydney Morning Herald http://smh.com.au/articles/2005/08/15/1123957975863.html?oneclick=true |
1,2,3 | Ibid. |
[4] | "Few beefs over laboratory-grown meat," Tuesday August 16, 2005, The Guardian, http://www.guardian.co.uk/letters/story/0,,1549781,00.html |
[5] | P.D. Edelman, D.C. McFarland, V.A. Mironov and J.G. Matheny, "In Vitro-Cultured Meat Production," Tissue Engineering, Volume 11, Number 5/6, 2005, p. 659. |
[6] | Op.Cit., TheBostonChannel.com For this quotation in its full context, see the final section of this essay. |
[7] | Op.Cit., Matheny et al. |
[8] | Op.Cit., Matheny et al, p. 660. |
[9] | Ibid., pp. 659-660. |
[10] | Ibid.. |
[11] | Ibid., p. 661. |
[12] | Ibid. |
[13] | Ibid., emphasis added. |
[14] | Op.Cit., TheBostonChannel.com |
[15] | Op.Cit., Matheny et al, p. 661. |
[16] | Moe, Kristine. "Should the Nazi Research Data Be Cited?" Hastings Center Report, Vol. 14 No. 6, December 1984. |
[17] | Although I hold the view that most vivisection conducted upon non-human animals does not result in human diseases being cured, surely there are a few instances in which this has happened. To quote George Bernard Shaw, "If you attempt to controvert a vivisectionist by showing that the experiment he has performed has not led to any useful result, you imply that if it had led to a useful result you would consider his experiment justified. Now, I am not prepared to concede that position." |
[18] | Op.Cit., TheBostonChannel.com, emphasis added. |
[19] | "Few beefs over laboratory-grown meat," Tuesday August 16, 2005, The Guardian, http://www.guardian.co.uk/letters/story/0,,1549781,00.html |
[20] | Op.Cit., Matheny et al, p. 660. |
[21] | For example, the interest in not feeling pain and the interest in not being deprived of future experiences that would result from death. |
[22] | Some writers argue that it is immoral to use Nazi data. See the text that follows and note 24. |
[23] | The practice of supposed "vegans" eating animal products that have been discarded, especially in rubbish bins. |
[24] | Some hold the view that using potentially life-saving Nazi data is always fundamentally immoral. If this view were held, then consistency would require that - if a hunter killed a non-human animal and left the body in the woods - it would always be immoral for a starving third party to eat that body in order to survive. These views, and their opposites, are both consistent with all of the claims made in this essay. |
Wednesday, March 17, 2010
Irish Colcannon and Irish Soda Bread
2 pounds Yukon Gold potatoes, peeled and diced
1 tablespoon olive oil
1 yellow onion, chopped
1 leek (white part only), rinsed and chopped
2 garlic cloves, minced
3 cups kale, finely shredded
3 cups green cabbage, finely shredded
Salt and pepper to taste
1/2 cup non-hydrogenated margarine
3/4 cup hot soymilk
1. Place the potatoes in a saucepan with enough cold water to cover. Bring to a boil over high heat. Reduce heat to medium-low, salt the water, cover, and simmer until tender, 15 to 20 minutes.
2. While the potatoes are cooking, heat the oil in a large saucepan over medium heat. Add the onion, leek, and garlic, cover and cook until softened, about 5 minutes. Add the kale and cabbage, season with salt and pepper, cover, and cook until tender, about 10 minutes.
3. When potatoes are cooked, drain and return to the pot. Add the margarine and soymilk, and mash with a potato masher. Stir in the kale and cabbage mixture, season again if necessary, and serve hot.
- 1-1/4 cups soymilk
- 1 tablespoon white vinegar
- 1 tablespoon canola oil
- 3 cups unbleached all-purpose flour
- 1 teaspoon sugar
- 1 teaspoon baking soda
- 1/2 teaspoon baking powder
- 1/2 teaspoon salt
- 1/2 cup raisins
- Preheat oven to 375 degrees. Combine the soymilk, vinegar, and oil in a bowl and set aside.
- In a large bowl, combine the flour, sugar, baking soda, baking powder, and salt until blended. Stir in the raisins. Add the soymilk mixture and mix well to make a stiff dough.
- Shape dough into a round loaf and place on a lightly-oiled baking sheet. Pat the top down slightly, then use a sharp knife to cut an X shape on top. Bake until golden brown, about 45 minutes, or until a toothpick inserted in the center comes out clean. Cool on a wire rack.