| Veganism as status passage: The process of becoming a vegan among youths in Sweden Appetite, Volume 41, Issue 1, August 2003, Pages 61-67 Christel L. Larsson, Ulla Rönnlund, Gunnar Johansson, Lars Dahlgren |
| Change in quality of life and immune markers after a stay at a raw vegan institute: A pilot study Complementary Therapies in Medicine, Volume 16, Issue 3, June 2008, Pages 124-130 Lilli B. Link, Najeeb S. Hussaini, Judith S. Jacobson |
| Factors affecting adherence to a raw vegan diet Complementary Therapies in Clinical Practice, Volume 14, Issue 1, February 2008, Pages 53-59 Lilli B Link, Judith S Jacobson |
| Iodine status in vegans consuming a living food diet Nutrition Research, Volume 14, Issue 12, December 1994, Pages 1789-1795 A-L Rauma, M-L Törmälä, M Nenonen, O Hänninen |
| Allaitement maternel et végétalisme Journal de Gynecologie Obstetrique et Biologie de la Reproduction, Volume 34, Issue 6, October 2005, Pages 610-612 J. Wagnon, B. Cagnard, L. Bridoux-Henno, Y. Tourtelier, J.-Y. Grall, A. Dabadie |
| An unusual case of atrioventricular heart block in a young vegan International Journal of Cardiology, Volume 125, Issue 1, 28 March 2008, Pages e12-e13 Tim Lockie, Matt Willcocks, Derek Harrington |
| Considerations in Planning Vegan Diets: Children Journal of the American Dietetic Association, Volume 101, Issue 6, June 2001, Pages 661-669 VIRGINIA MESSINA, ANN REED MANGELS |
| The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy Medical Hypotheses, Volume 72, Issue 2, February 2009, Pages 125-128 Mark F. McCarty, Jorge Barroso-Aranda, Francisco Contreras |
| Effects of a low-fat vegan diet and a Step II diet on macro- and micronutrient intakes in overweight postmenopausal women Nutrition, Volume 20, Issue 9, September 2004, Pages 738-746 Gabrielle M. Turner-McGrievy, Neal D. Barnard, Anthony R. Scialli, Amy J. Lanou |
| Young Swedish Vegans Have Different Sources of Nutrients than Young Omnivores Journal of the American Dietetic Association, Volume 105, Issue 9, September 2005, Pages 1438-1441 Christel L. Larsson, Gunnar K. Johansson |
| Considerations in planning vegan diets: infants Journal of the American Dietetic Association, Volume 101, Issue 6, June 2001, Pages 670-677 Ann Reed Mangels, Virginia Messina |
| Antioxidants in vegan diet and rheumatic disorders Toxicology, Volume 155, Issues 1-3, 30 November 2000, Pages 45-53 O. Hänninen, K. Kaartinen, A. -L. Rauma, M. Nenonen, R. Törrönen, S. Häkkinen, H. Adlercreutz, J. Laakso |
| Changes in Nutrient Intake and Dietary Quality among Participants with Type 2 Diabetes Following a Low-Fat Vegan Diet or a Conventional Diabetes Diet for 22 Weeks Journal of the American Dietetic Association, Volume 108, Issue 10, October 2008, Pages 1636-1645 Gabrielle M. Turner-McGrievy, Neal D. Barnard, Joshua Cohen, David J.A. Jenkins, Lise Gloede, Amber A. Green |
| A Low-Fat Vegan Diet Elicits Greater Macronutrient Changes, but Is Comparable in Adherence and Acceptability, Compared with a More Conventional Diabetes Diet among Individuals with Type 2 Diabetes Journal of the American Dietetic Association, Volume 109, Issue 2, February 2009, Pages 263-272 Neal D. Barnard, Lise Gloede, Joshua Cohen, David J.A. Jenkins, Gabrielle Turner-McGrievy, Amber A. Green, Hope Ferdowsian |
| Nutrient Adequacy of a Very Low-Fat Vegan Diet Journal of the American Dietetic Association, Volume 105, Issue 9, September 2005, Pages 1442-1446 Stacey R. Dunn-Emke, Gerdi Weidner, Elaine B. Pettengill, Ruth O. Marlin, Christine Chi, Dean M. Ornish |
| Shifting from conventional diet to an uncooked vegan diet reversibly alters serum lipid and apolipoprotein levels Nutrition Research, Volume 12, Issue 12, December 1992, Pages 1431-1440 Wen Hua Ling, Matti Laitinen, Osmo Hänninen |
| The nutritional adequacy of a limited vegan diet for a controlled ecological life-support system Advances in Space Research, Volume 18, Issues 4-5, 1996, Pages 63-72 P. R. Saha, P. R. Trumbo |
| Acceptability of a Therapeutic Low-Fat, Vegan Diet in Premenopausal Women Journal of Nutrition Education, Volume 32, Issue 6, November 2000, Pages 314-319 Neal Barnard, Anthony R. Scialli, Patricia Bertron, Donna Hurlock, Kalia Edmonds |
| A comparison between meat and vegan protein diet in patients with mild chronic hepatic encephalopathy Clinical Nutrition, Volume 6, Issue 3, August 1987, Pages 169-174 T. Jonung, B. Jeppsson, U. Åslund, B. M. Nair |
| A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events Medical Hypotheses, Volume 63, Issue 3, 2004, Pages 419-425 Mark F. McCarty |
| Tryptophan content of vegan and omnivorous one-day mixed food diet samples Food Chemistry, Volume 7, Issue 2, September 1981, Pages 105-108 Baboo M. Nair, Rickard Öste, Ingrid Andersson |
| IGF-I activity may be a key determinant of stroke risk – a cautionary lesson for vegans Medical Hypotheses, Volume 61, Issue 3, September 2003, Pages 323-334 M. F. McCarty |
| Dietary Intake of Vitamin D in Premenopausal, Healthy Vegans was Insufficient to Maintain Concentrations of Serum 25-hydroxyvitamin D and Intact Parathyroid Hormone Within Normal Ranges During the Winter in Finland Journal of the American Dietetic Association, Volume 100, Issue 4, April 2000, Pages 434-441 TERHI AULIKKI OUTILA, MERJA ULLA MARGAREETTA KÄRKKÄINEN, RIITTA HELENA SEPPÄNEN, CHRISTEL JOHANNA EMILIA LAMBERG-ALLARDT |
| A preliminary fast may potentiate response to a subsequent low-salt, low-fat vegan diet in the management of hypertension – fasting as a strategy for breaking metabolic vicious cycles Medical Hypotheses, Volume 60, Issue 5, May 2003, Pages 624-633 M. F. McCarty |
| A Very-Low-Fat Vegan Diet Increases Intake of Protective Dietary Factors and Decreases Intake of Pathogenic Dietary Factors Journal of the American Dietetic Association, Volume 108, Issue 2, February 2008, Pages 347-356 Antonella Dewell, Gerdi Weidner, Michael D. Sumner, Christine S. Chi, Dean Ornish |
| Estimated Net Acid Excretion Inversely Correlates With Urine pH in Vegans, Lacto-Ovo Vegetarians, and Omnivores Journal of Renal Nutrition, Volume 18, Issue 5, September 2008, Pages 456-465 Lynne M. Ausman, Lauren M. Oliver, Barry R. Goldin, Margo N. Woods, Sherwood L. Gorbach, Johanna T. Dwyer |
| A moderately low phosphate intake may provide health benefits analogous to those conferred by UV light – a further advantage of vegan diets Medical Hypotheses, Volume 61, Issues 5-6, November-December 2003, Pages 543-560 M. F. McCarty |
| A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process Medical Hypotheses, Volume 60, Issue 6, June 2003, Pages 784-792 Mark F. McCarty |
| The low-AGE content of low-fat vegan diets could benefit diabetics – though concurrent taurine supplementation may be needed to minimize endogenous AGE production Medical Hypotheses, Volume 64, Issue 2, 2005, Pages 394-398 Mark F. McCarty |
| Irreversible subacute sclerotic combined degeneration of the spinal cord in a vegan subject Nutrition, Volume 23, Issues 7-8, July-August 2007, Pages 622-624 Filippo Brocadello, Giorgio Levedianos, Francesco Piccione, Renzo Manara, Francesco Francini Pesenti |
| Angina and vegan diet American Heart Journal, Volume 93, Issue 6, June 1977, Pages 803-805 F.R. Ellis, T.A.B. Sanders |
| Ergocalciferol Supplementation May Positively Affect Lumbar Spine Bone Mineral Density of Vegans Journal of the American Dietetic Association, Volume 100, Issue 6, June 2000, Page 629 TERHI A. OUTILA, CHRISTEL J. E. LAMBERG-ALLARDT |
| Assessment of Iodine Intake and Iodine Status in Vegans Comprehensive Handbook of Iodine, 2009, Pages 429-436 Helen J. Lightowler |
| Simply Vegan: Quick Vegetarian Meals, 3rd Ed. Wasserman D, 1999. From The Vegetarian Resource Group, P.O. Box 1463, Baltimore, MD 21203, (410) 366-8343, cookbook, 224 pp, $12.95, 2.05 S+H, ISBN 0-931411-20-3. Journal of Nutrition Education, Volume 32, Issue 6, November 2000, Pages 357-358 Elena M. Byrne |
| A Successful Diet for Vegan Children Nourishes the Child Journal of the American Dietetic Association, Volume 101, Issue 6, June 2001, Page 669 Tony Peregrin |
| Main food sources of selected nutrients among vegans in the United States Journal of the American Dietetic Association, Volume 104, Supplement 2, August 2004, Page 60 P Dyett, E Haddad, J Sabaté |
| DEATH AFTER VEGAN DIET The Lancet, Volume 292, Issue 7560, 20 July 1968, Page 170 David Haler |
| DEATH AFTER VEGAN DIET The Lancet, Volume 292, Issue 7558, 6 July 1968, Pages 44-45 F. R. Ellis, M. E. A. Powell, AliN. Kuktha |
| D. Wasserman and R. Mangels, Simply Vegan: Quick Vegetarian Meals , From The Vegetarian Resource Group, Baltimore, MD (1995) ISBN 0-931411-15-7 P.O. Box 1463, 21203, (410) 366-8343,224 pp, softcover, $14.00. Journal of Nutrition Education, Volume 29, Issue 1, January 1997, Pages 49-50 Joanne K. Gardner |
| Iodine Deficiency in Vegetarian and Vegan Diets: Evidence-Based Review of the World’s Literature on Iodine Content in Vegetarian Diets Comprehensive Handbook of Iodine, 2009, Pages 521-531 Cheryl Fields, Jonathan Borak |
| D. Wasserman, Conveniently Vegan , From the Vegetarian Resource Group, P.O. Box 1463, Baltimore, MD 21203 (1997) ISBN 0-931411-18-1 208 pp, softcover, $15.00. Journal of Nutrition Education, Volume 30, Issue 2, March 1998, Page 126 Jean Allen, Carol Seaborn |
| Favorable impact of a vegan diet with exercise on hemorheology: implications for control of diabetic neuropathy Medical Hypotheses, Volume 58, Issue 6, June 2002, Pages 476-486 Mark F. McCarty |
| Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity Medical Hypotheses, Volume 53, Issue 6, December 1999, Pages 459-485 M. F. McCarty |
| Anémie et boiterie chez un adolescent végétalienAnemia and lameness in a vegan adolescent. Archives de Pédiatrie, Volume 8, Issue 1, January 2001, Pages 62-65 R. Chiron, A. Dabadie, V. Gandemer-Delignieres, M. Balençon, E. Legall, M. Roussey |
| Polyunsaturated fatty acid status of Dutch vegans and omnivores Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 63, Issue 5, November 2000, Pages 279-285 M. R. Fokkema, D. A. J. Brouwer, M. B. Hasperhoven, Y. Hettema, W. J. E. Bemelmans, F. A. J. Muskiet |
| Analysis of the Foods Offered for Lacto-Ovo-Vegetarians and Vegans in a University's Student Cafeteria Journal of the American Dietetic Association, Volume 97, Issue 9, Supplement 1, September 1997, Page A40 M. M. Derricote, S. L McWhinney |
| Does a vegan diet reduce risk for Parkinson’s disease? Medical Hypotheses, Volume 57, Issue 3, September 2001, Pages 318-323 M.F. McCarty |
| Upregulation of lymphocyte apoptosis as a strategy for preventing and treating autoimmune disorders: a role for whole-food vegan diets, fish oil and dopamine agonists Medical Hypotheses, Volume 57, Issue 2, August 2001, Pages 258-275 M. F. McCarty |
| Attitudes towards following meat, vegetarian and vegan diets: an examination of the role of ambivalence Appetite, Volume 37, Issue 1, August 2001, Pages 15-26 R. Povey, B. Wellens, M. Conner |
| Vegan Diet-Based Lifestyle Program Rapidly Lowers Homocysteine Levels Preventive Medicine, Volume 30, Issue 3, March 2000, Pages 225-233 David J. DeRose, Zeno L. Charles-Marcel, Judith M. Jamison, Joshua E. Muscat, Marc A. Braman, Gerard D. McLane, J. Keith Mullen |
| Short-term supplementation of low-dose γ -linolenic acid (GLA), α -linolenic acid (ALA), or GLA plus ALA does not augment LCP ω 3 status of Dutch vegans to an appreciable extent Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 63, Issue 5, November 2000, Pages 287-292 M. R. Fokkema, D. A. J. Brouwer, M. B. Hasperhoven, I. A. Martini, F. A. J. Muskiet |
| Conséquences de l’allaitement maternel exclusif chez le nouveau-né de mère végétalienne – À propos d’un cas Archives de Pédiatrie, Volume 16, Issue 11, November 2009, Pages 1461-1463 A. Mariani, S. Chalies, E. Jeziorski, C. Ludwig, M. Lalande, M. Rodière |
| Vegan diet alleviates fibromyalgia symptoms Pathophysiology, Volume 5, Supplement 1, June 1998, Page 264 K. Kaartinen, K. Lammi, M. Hypen, M. Nenonen, O. Hänninen |
| Uncooked, lactobacilli-rich, vegan food and rheumatoid arthritis: Nenonen MT, Helve TA, Rauma AL, Hanninen OO.British Journal of Rheumatology 1998; 737: 274–281 Complementary Therapies in Medicine, Volume 7, Issue 1, March 1999, Page 49 |
| We-P14:488 Effect of a weight reducing high protein vegan diet on serum lipids Atherosclerosis Supplements, Volume 7, Issue 3, 2006, Page 455 J.M.W. Wong, A. Esfahani, C.W.C. Kendall, D.J.A. Jenkins |
| Prolonged exclusive breast-feeding from vegan mother causing an acute onset of isolated methylmalonic aciduria due to a mild mutase deficiency Clinical Nutrition, Volume 19, Issue 2, April 2000, Pages 137-139 F. Ciani, G. M. Poggi, E. Pasquini, M. A. Donati, E. Zammarchi |
| Attitudes, Practices, and Beliefs of Individuals Consuming a Raw Foods Diet EXPLORE: The Journal of Science and Healing, Volume 1, Issue 4, July 2005, Pages 272-277 Suzanne Havala Hobbs |
| Iodine-deficient vegetarians: A hypothetical perchlorate-susceptible population? Regulatory Toxicology and Pharmacology, Volume 42, Issue 1, June 2005, Pages 37-46 Cheryl Fields, Michael Dourson, Jonathan Borak |
| Nutritional Counseling for Vegetarians During Pregnancy and Lactation Journal of Midwifery & Women's Health, Volume 53, Issue 1, January-February 2008, Pages 37-44 Debra S. Penney, Kathleen G. Miller |
| Integrated graphical approach to knowledge representation and acquisition Knowledge-Based Systems, Volume 1, Issue 5, December 1988, Pages 301-309 Ladan Esfahani, John Kellett |
| Particularités du senior végétarien Médecine des Maladies Métaboliques, Volume 3, Issue 4, September 2009, Pages 380-385 J.-M. Lecerf |
| The potential of diet to alter disease processes Nutrition Research, Volume 14, Issue 12, December 1994, Pages 1853-1896 R.W. Hubbard, A. Mejia, M. Horning |
| Is vegetable protein more beneficial to bone than animal protein? International Congress Series, Volume 1297, March 2007, Pages 310-318 S.A. Lanham-New, W.T.K. Lee, D.J. Torgerson, D.J. Millward |
| Efficacy and Safety of a Very-Low-Protein Diet When Postponing Dialysis in the Elderly: A Prospective Randomized Multicenter Controlled Study American Journal of Kidney Diseases, Volume 49, Issue 5, May 2007, Pages 569-580 Giuliano Brunori, Battista F. Viola, Giovanni Parrinello, Vincenzo De Biase, Giovanna Como, Vincenzo Franco, Giacomo Garibotto, Roberto Zubani, Giovanni C. Cancarini |
| Common Foods and Farming Methods Thought to Promote Health: What the Data Show Primary Care: Clinics in Office Practice, Volume 35, Issue 4, December 2008, Pages 769-788 John Chahbazi, Shelly Grow |
| Morphological Studies of the Predatory Ladybird Beetle Stethorus vagans (Blackburn) (Coleoptera: Coccinellidae) Journal of Asia-Pacific Entomology, Volume 5, Issue 1, May 2002, Pages 29-33 Inamullah Khan, Robert Spooner-Hart, Peter Bailey, Said Khan Khalil, Farman Ullah |
| Dietary saturate/unsaturate ratio as a determinant of adiposity Medical Hypotheses, In Press, Corrected Proof, Available online 20 January 2010 Mark F. McCarty |
| DHA status of vegetarians Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 81, Issues 2-3, August-September 2009, Pages 137-141 Thomas A.B. Sanders |
| The influence of a vegetarian diet on the fatty acid composition of human milk and the essential fatty acid status of the infant The Journal of Pediatrics, Volume 120, Issue 4, Part 2, April 1992, Pages S71-S77 T.A.B Sanders, Sheela Reddy |
| Position of the American Dietetic Association: Vegetarian Diets Journal of the American Dietetic Association, Volume 109, Issue 7, July 2009, Pages 1266-1282 |
| Un adolescent végétalien Archives de Pédiatrie, Volume 8, Issue 8, August 2001, Page 896 R. Lehmann |
| Un adolescent végétalien.Réponse des auteurs à la lettre du président de lUnion franco-belge des églises adventistes du septième jour Archives de Pédiatrie, Volume 8, Issue 8, August 2001, Page 896 A. Dabadie |
| Sub-optimal taurine status may promote platelet hyperaggregability in vegetarians Medical Hypotheses, Volume 63, Issue 3, 2004, Pages 426-433 Mark F. McCarty |
| Position of the American Dietetic Association and Dietitians of Canada: Vegetarian diets Journal of the American Dietetic Association, Volume 103, Issue 6, June 2003, Pages 748-765 |
| Normalizing ideological food choice and eating practices. Identity work in online discussions on veganism Appetite, Volume 52, Issue 3, June 2009, Pages 621-630 Petra Sneijder, Hedwig te Molder |
| Effects of Plant-Based Diets on Plasma Lipids The American Journal of Cardiology, Volume 104, Issue 7, 1 October 2009, Pages 947-956 Hope R. Ferdowsian, Neal D. Barnard |
| Mutagens in human urine: effects of cigarette smoking and diet Mutation Research/Genetic Toxicology, Volume 158, Issue 3, December 1985, Pages 149-157 Isaac M. Sasson, Daniel T. Coleman, Edmond J. LaVoie, Dietrich Hoffmann, Ernst L. Wynder |
| A wholly nutritional ‘multifocal angiostatic therapy’ for control of disseminated cancer Medical Hypotheses, Volume 61, Issue 1, July 2003, Pages 1-15 M. F. McCarty |
| A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets Medical Hypotheses, Volume 62, Issue 1, January 2004, Pages 62-71 M. F. McCarty |
| A methodology for knowledge engineering using an interactive graphical tool for knowledge modelling Artificial Intelligence in Engineering, Volume 4, Issue 2, April 1989, Pages 92-102 J. M. Kellett, G. Winstanley, J. T. Boardman |
| Nutrient Intakes and Eating Behavior see of Vegetarian and Nonvegetarian Women Journal of the American Dietetic Association, Volume 95, Issue 2, February 1995, Pages 180-189 K. CHRISTINA JANELLE, SUSAN I. BARR |
| The effects of a low-fat, plant-based dietary intervention on body weight, metabolism, and insulin sensitivity The American Journal of Medicine, Volume 118, Issue 9, September 2005, Pages 991-997 Neal D. Barnard, Anthony R. Scialli, Gabrielle Turner-McGrievy, Amy J. Lanou, Jolie Glass |
| Diet and Rheumatoid Arthritis: A Review of the Literature Seminars in Arthritis and Rheumatism, Volume 35, Issue 2, October 2005, Pages 77-94 Lisa K. Stamp, Michael J. James, Leslie G. Cleland |
| Dietary intake and nutritional status of vegetarian and omnivorous preschool children and their parents in Taiwan Nutrition Research, Volume 28, Issue 7, July 2008, Pages 430-436 Chin-En Yen, Chi-Hua Yen, Men-Chung Huang, Chien-Hsiang Cheng, Yi-Chia Huang |
| Spinal Bone Mineral Density in Premenopausal Vegetarian and Nonvegetarian Women: Cross-sectional and Prospective Comparisons Journal of the American Dietetic Association, Volume 98, Issue 7, July 1998, Pages 760-765 SUSAN I. BARR, JERILYNN C. PRIOR, K. CHRISTINA JANELLE, BRIAN C. LENTLE |
| D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes Nutrition, Volume 25, Issue 1, January 2009, Pages 58-65 Neal D. Barnard, Ernest P. Noble, Terry Ritchie, Joshua Cohen, David J.A. Jenkins, Gabrielle Turner-McGrievy, Lise Gloede, Amber A. Green, Hope Ferdowsian |
| Plasma arachidonic acid and serum thromboxane B2 concentrations in phenylketonuric children negatively correlate with dietary compliance Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 56, Issue 3, March 1997, Pages 219-222 C. Agostoni, F. Marangoni, E. Riva, M. Giovannini, C. Galli |
| Association between vegetarian diet and menstrual problems in young women: a case presentation and brief review Journal of Pediatric and Adolescent Gynecology, Volume 16, Issue 5, October 2003, Pages 319-323 Joan Griffith, Hatim Omar |
| Iatrogenic lipodystrophy in HIV patients – the need for very-low-fat diets Medical Hypotheses, Volume 61, Issues 5-6, November-December 2003, Pages 561-566 M. F. McCarty |
| An ezetimibe–policosanol combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without side effects Medical Hypotheses, Volume 64, Issue 3, 2005, Pages 636-645 Mark F. McCarty |
| Survey of arsenic and its speciation in rice products such as breakfast cereals, rice crackers and Japanese rice condiments Environment International, Volume 35, Issue 3, April 2009, Pages 473-475 Guo-Xin Sun, Paul N. Williams, Yong-Guan Zhu, Claire Deacon, Anne-Marie Carey, Andrea Raab, Joerg Feldmann, Andrew A. Meharg |
| Informed Consent: Cultural and Religious Issues Associated with the Use of Allogeneic and Xenogeneic Mesh Products Journal of the American College of Surgeons, Volume 210, Issue 4, April 2010, Pages 402-410 Eric D. Jenkins, Michael Yip, Lora Melman, Margaret M. Frisella, Brent D. Matthews |
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| Phytosterol-Deficient and High-Phytosterol Diets Developed for Controlled Feeding Studies Journal of the American Dietetic Association, Volume 109, Issue 12, December 2009, Pages 2043-2051 Susan B. Racette, Catherine Anderson Spearie, Katherine M. Phillips, Xiaobo Lin, Lina Ma, Richard E. Ostlund Jr |
| Perceptions and practices of self-defined current vegetarian, former vegetarian, and nonvegetarian women Journal of the American Dietetic Association, Volume 102, Issue 3, March 2002, Pages 354-360 Susan I Barr, Gwen E Chapman |
| Low-insulin-response diets may decrease plasma C-reactive protein by influencing adipocyte function Medical Hypotheses, Volume 64, Issue 2, 2005, Pages 385-387 Mark F. McCarty |
| Chiral signatures of PCB#s 95 and 149 in indoor air, grass, duplicate diets and human faeces Chemosphere, Volume 63, Issue 8, May 2006, Pages 1368-1376 Stuart Harrad, Jianzhang Ren, Sadegh Hazrati, Matthew Robson |
| Policosanol safely down-regulates HMG-CoA reductase – potential as a component of the Esselstyn regimen Medical Hypotheses, Volume 59, Issue 3, September 2002, Pages 268-279 M. F. McCarty |
Abstract
Many of the wide-ranging health benefits conferred by statin therapy are mediated, not by reductions in LDL cholesterol, but rather by inhibition of isoprenylation reactions essential to the activation of Rho family GTPases; this may be the mechanism primarily responsible for the favorable impact of statins on risk for ischemic stroke, senile dementia, and fractures, as well as the anti-hypertensive and platelet-stabilizing actions of these drugs. Indeed, the extent of these benefits is such as to suggest that most adults would be wise to take statins; however, owing to the significant expense of statin therapy, as well as to the potential for dangerous side effects that mandates regular physician follow-up, this strategy appears impractical. However, policosanol, a mixture of long-chain aliphatic alcohols extractable from sugar cane wax, has shown cholesterol-lowering potency comparable to that of statins, and yet appears to be devoid of toxic risk. Recent evidence indicates that policosanol down-regulates cellular expression of HMG-CoA reductase, and thus has the potential to suppress isoprenylation reactions much like statins do. Consistent with this possibility, the results of certain clinical and animal studies demonstrate that policosanol has many effects analogous to those of statins that are not likely explained by reductions of LDL cholesterol. However, unlike statins, policosanol does not directly inhibit HMG-CoA reductase, and even in high concentrations it fails to down-regulate this enzyme by more than 50% – thus likely accounting for the safety of this nutraceutical. In light of the fact that policosanol is quite inexpensive and is becoming available as a non-prescription dietary supplement, it may represent a practical resource that could enable the general public to enjoy health benefits comparable to those conferred by statins. In a long-term clinical study enrolling patients with significant symptomatic coronary disease, Esselstyn has demonstrated that a low-fat, whole-food vegan diet, coupled with sufficient statin therapy to maintain serum cholesterol below 150 mg/dL, can stop the progression of coronary disease and virtually eliminate further risk for heart attack. A comparable regimen, in which policosanol is used in place of statins, may represent a practical strategy whereby nearly everyone willing to commit to health-protective eating can either prevent coronary disease, or prevent pre-existing coronary disease from progressing to a life-threatening event.
| Dietary omega-3 fatty acids for women Biomedicine & Pharmacotherapy, Volume 61, Issues 2-3, February-April 2007, Pages 105-112 Jean-Marie Bourre |
| Levels of dioxins, dibenzofurans, PCB and DDE congeners in pooled food samples collected in 1995 at supermarkets across the United States Chemosphere, Volume 34, Issues 5-7, March-April 1997, Pages 1437-1447 Arnold Schecter, Paul Cramer, Kathy Boggess, John Stanley, James R. Olson |
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