Sunday, April 04, 2010

Vegan as the American Heart Association sees it


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Veganism as status passage: The process of becoming a vegan among youths in Sweden
AppetiteVolume 41, Issue 1August 2003Pages 61-67
Christel L. Larsson, Ulla Rönnlund, Gunnar Johansson, Lars Dahlgren
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Change in quality of life and immune markers after a stay at a raw vegan institute: A pilot study
Complementary Therapies in MedicineVolume 16, Issue 3June 2008Pages 124-130
Lilli B. Link, Najeeb S. Hussaini, Judith S. Jacobson
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Factors affecting adherence to a raw vegan diet
Complementary Therapies in Clinical PracticeVolume 14, Issue 1February 2008Pages 53-59
Lilli B Link, Judith S Jacobson
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Iodine status in vegans consuming a living food diet
Nutrition ResearchVolume 14, Issue 12December 1994Pages 1789-1795
A-L Rauma, M-L Törmälä, M Nenonen, O Hänninen
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Allaitement maternel et végétalisme
Journal de Gynecologie Obstetrique et Biologie de la ReproductionVolume 34, Issue 6October 2005Pages 610-612
J. Wagnon, B. Cagnard, L. Bridoux-Henno, Y. Tourtelier, J.-Y. Grall, A. Dabadie
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An unusual case of atrioventricular heart block in a young vegan
International Journal of CardiologyVolume 125, Issue 128 March 2008Pages e12-e13
Tim Lockie, Matt Willcocks, Derek Harrington
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Considerations in Planning Vegan Diets: Children
Journal of the American Dietetic AssociationVolume 101, Issue 6June 2001Pages 661-669
VIRGINIA MESSINA, ANN REED MANGELS
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The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy
Medical HypothesesVolume 72, Issue 2February 2009Pages 125-128
Mark F. McCarty, Jorge Barroso-Aranda, Francisco Contreras
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Effects of a low-fat vegan diet and a Step II diet on macro- and micronutrient intakes in overweight postmenopausal women
NutritionVolume 20, Issue 9September 2004Pages 738-746
Gabrielle M. Turner-McGrievy, Neal D. Barnard, Anthony R. Scialli, Amy J. Lanou
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Young Swedish Vegans Have Different Sources of Nutrients than Young Omnivores
Journal of the American Dietetic AssociationVolume 105, Issue 9September 2005Pages 1438-1441
Christel L. Larsson, Gunnar K. Johansson
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Considerations in planning vegan diets: infants
Journal of the American Dietetic AssociationVolume 101, Issue 6June 2001Pages 670-677
Ann Reed Mangels, Virginia Messina
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Antioxidants in vegan diet and rheumatic disorders
ToxicologyVolume 155, Issues 1-330 November 2000Pages 45-53
O. Hänninen, K. Kaartinen, A. -L. Rauma, M. Nenonen, R. Törrönen, S. Häkkinen, H. Adlercreutz, J. Laakso
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imageimage Changes in Nutrient Intake and Dietary Quality among Participants with Type 2 Diabetes Following a Low-Fat Vegan Diet or a Conventional Diabetes Diet for 22 Weeks
Journal of the American Dietetic AssociationVolume 108, Issue 10October 2008Pages 1636-1645
Gabrielle M. Turner-McGrievy, Neal D. Barnard, Joshua Cohen, David J.A. Jenkins, Lise Gloede, Amber A. Green
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image A Low-Fat Vegan Diet Elicits Greater Macronutrient Changes, but Is Comparable in Adherence and Acceptability, Compared with a More Conventional Diabetes Diet among Individuals with Type 2 Diabetes
Journal of the American Dietetic AssociationVolume 109, Issue 2February 2009Pages 263-272
Neal D. Barnard, Lise Gloede, Joshua Cohen, David J.A. Jenkins, Gabrielle Turner-McGrievy, Amber A. Green, Hope Ferdowsian
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Nutrient Adequacy of a Very Low-Fat Vegan Diet
Journal of the American Dietetic AssociationVolume 105, Issue 9September 2005Pages 1442-1446
Stacey R. Dunn-Emke, Gerdi Weidner, Elaine B. Pettengill, Ruth O. Marlin, Christine Chi, Dean M. Ornish
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Shifting from conventional diet to an uncooked vegan diet reversibly alters serum lipid and apolipoprotein levels
Nutrition ResearchVolume 12, Issue 12December 1992Pages 1431-1440
Wen Hua Ling, Matti Laitinen, Osmo Hänninen
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The nutritional adequacy of a limited vegan diet for a controlled ecological life-support system
Advances in Space ResearchVolume 18, Issues 4-51996Pages 63-72
P. R. Saha, P. R. Trumbo
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Acceptability of a Therapeutic Low-Fat, Vegan Diet in Premenopausal Women
Journal of Nutrition EducationVolume 32, Issue 6November 2000Pages 314-319
Neal Barnard, Anthony R. Scialli, Patricia Bertron, Donna Hurlock, Kalia Edmonds
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A comparison between meat and vegan protein diet in patients with mild chronic hepatic encephalopathy
Clinical NutritionVolume 6, Issue 3August 1987Pages 169-174
T. Jonung, B. Jeppsson, U. Åslund, B. M. Nair
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A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events
Medical HypothesesVolume 63, Issue 32004Pages 419-425
Mark F. McCarty
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Tryptophan content of vegan and omnivorous one-day mixed food diet samples
Food ChemistryVolume 7, Issue 2September 1981Pages 105-108
Baboo M. Nair, Rickard Öste, Ingrid Andersson
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IGF-I activity may be a key determinant of stroke risk – a cautionary lesson for vegans
Medical HypothesesVolume 61, Issue 3September 2003Pages 323-334
M. F. McCarty
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Dietary Intake of Vitamin D in Premenopausal, Healthy Vegans was Insufficient to Maintain Concentrations of Serum 25-hydroxyvitamin D and Intact Parathyroid Hormone Within Normal Ranges During the Winter in Finland
Journal of the American Dietetic AssociationVolume 100, Issue 4April 2000Pages 434-441
TERHI AULIKKI OUTILA, MERJA ULLA MARGAREETTA KÄRKKÄINEN, RIITTA HELENA SEPPÄNEN, CHRISTEL JOHANNA EMILIA LAMBERG-ALLARDT
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A preliminary fast may potentiate response to a subsequent low-salt, low-fat vegan diet in the management of hypertension – fasting as a strategy for breaking metabolic vicious cycles
Medical HypothesesVolume 60, Issue 5May 2003Pages 624-633
M. F. McCarty
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A Very-Low-Fat Vegan Diet Increases Intake of Protective Dietary Factors and Decreases Intake of Pathogenic Dietary Factors
Journal of the American Dietetic AssociationVolume 108, Issue 2February 2008Pages 347-356
Antonella Dewell, Gerdi Weidner, Michael D. Sumner, Christine S. Chi, Dean Ornish
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Estimated Net Acid Excretion Inversely Correlates With Urine pH in Vegans, Lacto-Ovo Vegetarians, and Omnivores
Journal of Renal NutritionVolume 18, Issue 5September 2008Pages 456-465
Lynne M. Ausman, Lauren M. Oliver, Barry R. Goldin, Margo N. Woods, Sherwood L. Gorbach, Johanna T. Dwyer
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A moderately low phosphate intake may provide health benefits analogous to those conferred by UV light – a further advantage of vegan diets
Medical HypothesesVolume 61, Issues 5-6November-December 2003Pages 543-560
M. F. McCarty
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A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process
Medical HypothesesVolume 60, Issue 6June 2003Pages 784-792
Mark F. McCarty
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The low-AGE content of low-fat vegan diets could benefit diabetics – though concurrent taurine supplementation may be needed to minimize endogenous AGE production
Medical HypothesesVolume 64, Issue 22005Pages 394-398
Mark F. McCarty
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Irreversible subacute sclerotic combined degeneration of the spinal cord in a vegan subject
NutritionVolume 23, Issues 7-8July-August 2007Pages 622-624
Filippo Brocadello, Giorgio Levedianos, Francesco Piccione, Renzo Manara, Francesco Francini Pesenti
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Angina and vegan diet
American Heart JournalVolume 93, Issue 6June 1977Pages 803-805
F.R. Ellis, T.A.B. Sanders
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Ergocalciferol Supplementation May Positively Affect Lumbar Spine Bone Mineral Density of Vegans
Journal of the American Dietetic AssociationVolume 100, Issue 6June 2000Page 629
TERHI A. OUTILA, CHRISTEL J. E. LAMBERG-ALLARDT
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Assessment of Iodine Intake and Iodine Status in Vegans
Comprehensive Handbook of Iodine2009Pages 429-436
Helen J. Lightowler
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Simply Vegan: Quick Vegetarian Meals, 3rd Ed. Wasserman D, 1999. From The Vegetarian Resource Group, P.O. Box 1463, Baltimore, MD 21203, (410) 366-8343, cookbook, 224 pp, $12.95, 2.05 S+H, ISBN 0-931411-20-3.
Journal of Nutrition EducationVolume 32, Issue 6November 2000Pages 357-358
Elena M. Byrne
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A Successful Diet for Vegan Children Nourishes the Child
Journal of the American Dietetic AssociationVolume 101, Issue 6June 2001Page 669
Tony Peregrin
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Main food sources of selected nutrients among vegans in the United States
Journal of the American Dietetic AssociationVolume 104, Supplement 2August 2004Page 60
P Dyett, E Haddad, J Sabaté
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DEATH AFTER VEGAN DIET
The LancetVolume 292, Issue 756020 July 1968Page 170
David Haler
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DEATH AFTER VEGAN DIET
The LancetVolume 292, Issue 75586 July 1968Pages 44-45
F. R. Ellis, M. E. A. Powell, AliN. Kuktha
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D. Wasserman and R. Mangels, Simply Vegan: Quick Vegetarian Meals , From The Vegetarian Resource Group, Baltimore, MD (1995) ISBN 0-931411-15-7 P.O. Box 1463, 21203, (410) 366-8343,224 pp, softcover, $14.00.
Journal of Nutrition EducationVolume 29, Issue 1January 1997Pages 49-50
Joanne K. Gardner
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Iodine Deficiency in Vegetarian and Vegan Diets: Evidence-Based Review of the World’s Literature on Iodine Content in Vegetarian Diets
Comprehensive Handbook of Iodine2009Pages 521-531
Cheryl Fields, Jonathan Borak
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D. Wasserman, Conveniently Vegan , From the Vegetarian Resource Group, P.O. Box 1463, Baltimore, MD 21203 (1997) ISBN 0-931411-18-1 208 pp, softcover, $15.00.
Journal of Nutrition EducationVolume 30, Issue 2March 1998Page 126
Jean Allen, Carol Seaborn
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Favorable impact of a vegan diet with exercise on hemorheology: implications for control of diabetic neuropathy
Medical HypothesesVolume 58, Issue 6June 2002Pages 476-486
Mark F. McCarty
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Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity
Medical HypothesesVolume 53, Issue 6December 1999Pages 459-485
M. F. McCarty
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Anémie et boiterie chez un adolescent végétalienAnemia and lameness in a vegan adolescent.
Archives de PédiatrieVolume 8, Issue 1January 2001Pages 62-65
R. Chiron, A. Dabadie, V. Gandemer-Delignieres, M. Balençon, E. Legall, M. Roussey
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Polyunsaturated fatty acid status of Dutch vegans and omnivores
Prostaglandins, Leukotrienes and Essential Fatty AcidsVolume 63, Issue 5November 2000Pages 279-285
M. R. Fokkema, D. A. J. Brouwer, M. B. Hasperhoven, Y. Hettema, W. J. E. Bemelmans, F. A. J. Muskiet
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Analysis of the Foods Offered for Lacto-Ovo-Vegetarians and Vegans in a University's Student Cafeteria
Journal of the American Dietetic AssociationVolume 97, Issue 9, Supplement 1September 1997Page A40
M. M. Derricote, S. L McWhinney
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Does a vegan diet reduce risk for Parkinson’s disease?
Medical HypothesesVolume 57, Issue 3September 2001Pages 318-323
M.F. McCarty
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Upregulation of lymphocyte apoptosis as a strategy for preventing and treating autoimmune disorders: a role for whole-food vegan diets, fish oil and dopamine agonists
Medical HypothesesVolume 57, Issue 2August 2001Pages 258-275
M. F. McCarty
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Attitudes towards following meat, vegetarian and vegan diets: an examination of the role of ambivalence
AppetiteVolume 37, Issue 1August 2001Pages 15-26
R. Povey, B. Wellens, M. Conner
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Vegan Diet-Based Lifestyle Program Rapidly Lowers Homocysteine Levels
Preventive MedicineVolume 30, Issue 3March 2000Pages 225-233
David J. DeRose, Zeno L. Charles-Marcel, Judith M. Jamison, Joshua E. Muscat, Marc A. Braman, Gerard D. McLane, J. Keith Mullen
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Short-term supplementation of low-dose γ -linolenic acid (GLA), α -linolenic acid (ALA), or GLA plus ALA does not augment LCP ω 3 status of Dutch vegans to an appreciable extent
Prostaglandins, Leukotrienes and Essential Fatty AcidsVolume 63, Issue 5November 2000Pages 287-292
M. R. Fokkema, D. A. J. Brouwer, M. B. Hasperhoven, I. A. Martini, F. A. J. Muskiet
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Conséquences de l’allaitement maternel exclusif chez le nouveau-né de mère végétalienne – À propos d’un cas
Archives de PédiatrieVolume 16, Issue 11November 2009Pages 1461-1463
A. Mariani, S. Chalies, E. Jeziorski, C. Ludwig, M. Lalande, M. Rodière
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Vegan diet alleviates fibromyalgia symptoms
PathophysiologyVolume 5, Supplement 1June 1998Page 264
K. Kaartinen, K. Lammi, M. Hypen, M. Nenonen, O. Hänninen
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Uncooked, lactobacilli-rich, vegan food and rheumatoid arthritis: Nenonen MT, Helve TA, Rauma AL, Hanninen OO.British Journal of Rheumatology 1998; 737: 274–281
Complementary Therapies in MedicineVolume 7, Issue 1March 1999Page 49
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We-P14:488 Effect of a weight reducing high protein vegan diet on serum lipids
Atherosclerosis SupplementsVolume 7, Issue 32006Page 455
J.M.W. Wong, A. Esfahani, C.W.C. Kendall, D.J.A. Jenkins
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Prolonged exclusive breast-feeding from vegan mother causing an acute onset of isolated methylmalonic aciduria due to a mild mutase deficiency
Clinical NutritionVolume 19, Issue 2April 2000Pages 137-139
F. Ciani, G. M. Poggi, E. Pasquini, M. A. Donati, E. Zammarchi
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Attitudes, Practices, and Beliefs of Individuals Consuming a Raw Foods Diet
EXPLORE: The Journal of Science and HealingVolume 1, Issue 4July 2005Pages 272-277
Suzanne Havala Hobbs
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Iodine-deficient vegetarians: A hypothetical perchlorate-susceptible population?
Regulatory Toxicology and PharmacologyVolume 42, Issue 1June 2005Pages 37-46
Cheryl Fields, Michael Dourson, Jonathan Borak
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Nutritional Counseling for Vegetarians During Pregnancy and Lactation
Journal of Midwifery & Women's HealthVolume 53, Issue 1January-February 2008Pages 37-44
Debra S. Penney, Kathleen G. Miller
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Integrated graphical approach to knowledge representation and acquisition
Knowledge-Based SystemsVolume 1, Issue 5December 1988Pages 301-309
Ladan Esfahani, John Kellett
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Particularités du senior végétarien
Médecine des Maladies MétaboliquesVolume 3, Issue 4September 2009Pages 380-385
J.-M. Lecerf
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The potential of diet to alter disease processes
Nutrition ResearchVolume 14, Issue 12December 1994Pages 1853-1896
R.W. Hubbard, A. Mejia, M. Horning
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Is vegetable protein more beneficial to bone than animal protein?
International Congress SeriesVolume 1297March 2007Pages 310-318
S.A. Lanham-New, W.T.K. Lee, D.J. Torgerson, D.J. Millward
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Efficacy and Safety of a Very-Low-Protein Diet When Postponing Dialysis in the Elderly: A Prospective Randomized Multicenter Controlled Study
American Journal of Kidney DiseasesVolume 49, Issue 5May 2007Pages 569-580
Giuliano Brunori, Battista F. Viola, Giovanni Parrinello, Vincenzo De Biase, Giovanna Como, Vincenzo Franco, Giacomo Garibotto, Roberto Zubani, Giovanni C. Cancarini
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Common Foods and Farming Methods Thought to Promote Health: What the Data Show
Primary Care: Clinics in Office PracticeVolume 35, Issue 4December 2008Pages 769-788
John Chahbazi, Shelly Grow
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Morphological Studies of the Predatory Ladybird Beetle Stethorus vagans (Blackburn) (Coleoptera: Coccinellidae)
Journal of Asia-Pacific EntomologyVolume 5, Issue 1May 2002Pages 29-33
Inamullah Khan, Robert Spooner-Hart, Peter Bailey, Said Khan Khalil, Farman Ullah
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Dietary saturate/unsaturate ratio as a determinant of adiposity
Medical HypothesesIn Press, Corrected ProofAvailable online 20 January 2010
Mark F. McCarty
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DHA status of vegetarians
Prostaglandins, Leukotrienes and Essential Fatty AcidsVolume 81, Issues 2-3August-September 2009Pages 137-141
Thomas A.B. Sanders
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The influence of a vegetarian diet on the fatty acid composition of human milk and the essential fatty acid status of the infant
The Journal of PediatricsVolume 120, Issue 4, Part 2April 1992Pages S71-S77
T.A.B Sanders, Sheela Reddy
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Position of the American Dietetic Association: Vegetarian Diets
Journal of the American Dietetic AssociationVolume 109, Issue 7July 2009Pages 1266-1282
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Un adolescent végétalien
Archives de PédiatrieVolume 8, Issue 8August 2001Page 896
R. Lehmann
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Un adolescent végétalien.Réponse des auteurs à la lettre du président de lmodifier letter vertical lineUnion franco-belge des églises adventistes du septième jour
Archives de PédiatrieVolume 8, Issue 8August 2001Page 896
A. Dabadie
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Sub-optimal taurine status may promote platelet hyperaggregability in vegetarians
Medical HypothesesVolume 63, Issue 32004Pages 426-433
Mark F. McCarty
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Position of the American Dietetic Association and Dietitians of Canada: Vegetarian diets
Journal of the American Dietetic AssociationVolume 103, Issue 6June 2003Pages 748-765
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Normalizing ideological food choice and eating practices. Identity work in online discussions on veganism
AppetiteVolume 52, Issue 3June 2009Pages 621-630
Petra Sneijder, Hedwig te Molder
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Effects of Plant-Based Diets on Plasma Lipids
The American Journal of CardiologyVolume 104, Issue 71 October 2009Pages 947-956
Hope R. Ferdowsian, Neal D. Barnard
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Mutagens in human urine: effects of cigarette smoking and diet
Mutation Research/Genetic ToxicologyVolume 158, Issue 3December 1985Pages 149-157
Isaac M. Sasson, Daniel T. Coleman, Edmond J. LaVoie, Dietrich Hoffmann, Ernst L. Wynder
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A wholly nutritional ‘multifocal angiostatic therapy’ for control of disseminated cancer
Medical HypothesesVolume 61, Issue 1July 2003Pages 1-15
M. F. McCarty
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A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets
Medical HypothesesVolume 62, Issue 1January 2004Pages 62-71
M. F. McCarty
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A methodology for knowledge engineering using an interactive graphical tool for knowledge modelling
Artificial Intelligence in EngineeringVolume 4, Issue 2April 1989Pages 92-102
J. M. Kellett, G. Winstanley, J. T. Boardman
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Nutrient Intakes and Eating Behavior see of Vegetarian and Nonvegetarian Women
Journal of the American Dietetic AssociationVolume 95, Issue 2February 1995Pages 180-189
K. CHRISTINA JANELLE, SUSAN I. BARR
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The effects of a low-fat, plant-based dietary intervention on body weight, metabolism, and insulin sensitivity
The American Journal of MedicineVolume 118, Issue 9September 2005Pages 991-997
Neal D. Barnard, Anthony R. Scialli, Gabrielle Turner-McGrievy, Amy J. Lanou, Jolie Glass
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Diet and Rheumatoid Arthritis: A Review of the Literature
Seminars in Arthritis and RheumatismVolume 35, Issue 2October 2005Pages 77-94
Lisa K. Stamp, Michael J. James, Leslie G. Cleland
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Dietary intake and nutritional status of vegetarian and omnivorous preschool children and their parents in Taiwan
Nutrition ResearchVolume 28, Issue 7July 2008Pages 430-436
Chin-En Yen, Chi-Hua Yen, Men-Chung Huang, Chien-Hsiang Cheng, Yi-Chia Huang
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Spinal Bone Mineral Density in Premenopausal Vegetarian and Nonvegetarian Women: Cross-sectional and Prospective Comparisons
Journal of the American Dietetic AssociationVolume 98, Issue 7July 1998Pages 760-765
SUSAN I. BARR, JERILYNN C. PRIOR, K. CHRISTINA JANELLE, BRIAN C. LENTLE
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D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes
NutritionVolume 25, Issue 1January 2009Pages 58-65
Neal D. Barnard, Ernest P. Noble, Terry Ritchie, Joshua Cohen, David J.A. Jenkins, Gabrielle Turner-McGrievy, Lise Gloede, Amber A. Green, Hope Ferdowsian
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Plasma arachidonic acid and serum thromboxane B2 concentrations in phenylketonuric children negatively correlate with dietary compliance
Prostaglandins, Leukotrienes and Essential Fatty AcidsVolume 56, Issue 3March 1997Pages 219-222
C. Agostoni, F. Marangoni, E. Riva, M. Giovannini, C. Galli
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Association between vegetarian diet and menstrual problems in young women: a case presentation and brief review
Journal of Pediatric and Adolescent GynecologyVolume 16, Issue 5October 2003Pages 319-323
Joan Griffith, Hatim Omar
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Iatrogenic lipodystrophy in HIV patients – the need for very-low-fat diets
Medical HypothesesVolume 61, Issues 5-6November-December 2003Pages 561-566
M. F. McCarty
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An ezetimibe–policosanol combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without side effects
Medical HypothesesVolume 64, Issue 32005Pages 636-645
Mark F. McCarty
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Survey of arsenic and its speciation in rice products such as breakfast cereals, rice crackers and Japanese rice condiments
Environment InternationalVolume 35, Issue 3April 2009Pages 473-475
Guo-Xin Sun, Paul N. Williams, Yong-Guan Zhu, Claire Deacon, Anne-Marie Carey, Andrea Raab, Joerg Feldmann, Andrew A. Meharg
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Informed Consent: Cultural and Religious Issues Associated with the Use of Allogeneic and Xenogeneic Mesh Products
Journal of the American College of SurgeonsVolume 210, Issue 4April 2010Pages 402-410
Eric D. Jenkins, Michael Yip, Lora Melman, Margaret M. Frisella, Brent D. Matthews
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Binding of steroid hormones in vitro by water-insoluble dietary fiber
Nutrition ResearchVolume 8, Issue 11November 1988Pages 1223-1235
Crystal G. Whitten, Terry D. Shultz
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Phytosterol-Deficient and High-Phytosterol Diets Developed for Controlled Feeding Studies
Journal of the American Dietetic AssociationVolume 109, Issue 12December 2009Pages 2043-2051
Susan B. Racette, Catherine Anderson Spearie, Katherine M. Phillips, Xiaobo Lin, Lina Ma, Richard E. Ostlund Jr
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Perceptions and practices of self-defined current vegetarian, former vegetarian, and nonvegetarian women
Journal of the American Dietetic AssociationVolume 102, Issue 3March 2002Pages 354-360
Susan I Barr, Gwen E Chapman
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Low-insulin-response diets may decrease plasma C-reactive protein by influencing adipocyte function
Medical HypothesesVolume 64, Issue 22005Pages 385-387
Mark F. McCarty
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Chiral signatures of PCB#s 95 and 149 in indoor air, grass, duplicate diets and human faeces
ChemosphereVolume 63, Issue 8May 2006Pages 1368-1376
Stuart Harrad, Jianzhang Ren, Sadegh Hazrati, Matthew Robson
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Policosanol safely down-regulates HMG-CoA reductase – potential as a component of the Esselstyn regimen
Medical HypothesesVolume 59, Issue 3September 2002Pages 268-279
M. F. McCarty

Abstract

Many of the wide-ranging health benefits conferred by statin therapy are mediated, not by reductions in LDL cholesterol, but rather by inhibition of isoprenylation reactions essential to the activation of Rho family GTPases; this may be the mechanism primarily responsible for the favorable impact of statins on risk for ischemic stroke, senile dementia, and fractures, as well as the anti-hypertensive and platelet-stabilizing actions of these drugs. Indeed, the extent of these benefits is such as to suggest that most adults would be wise to take statins; however, owing to the significant expense of statin therapy, as well as to the potential for dangerous side effects that mandates regular physician follow-up, this strategy appears impractical. However, policosanol, a mixture of long-chain aliphatic alcohols extractable from sugar cane wax, has shown cholesterol-lowering potency comparable to that of statins, and yet appears to be devoid of toxic risk. Recent evidence indicates that policosanol down-regulates cellular expression of HMG-CoA reductase, and thus has the potential to suppress isoprenylation reactions much like statins do. Consistent with this possibility, the results of certain clinical and animal studies demonstrate that policosanol has many effects analogous to those of statins that are not likely explained by reductions of LDL cholesterol. However, unlike statins, policosanol does not directly inhibit HMG-CoA reductase, and even in high concentrations it fails to down-regulate this enzyme by more than 50% – thus likely accounting for the safety of this nutraceutical. In light of the fact that policosanol is quite inexpensive and is becoming available as a non-prescription dietary supplement, it may represent a practical resource that could enable the general public to enjoy health benefits comparable to those conferred by statins. In a long-term clinical study enrolling patients with significant symptomatic coronary disease, Esselstyn has demonstrated that a low-fat, whole-food vegan diet, coupled with sufficient statin therapy to maintain serum cholesterol below 150 mg/dL, can stop the progression of coronary disease and virtually eliminate further risk for heart attack. A comparable regimen, in which policosanol is used in place of statins, may represent a practical strategy whereby nearly everyone willing to commit to health-protective eating can either prevent coronary disease, or prevent pre-existing coronary disease from progressing to a life-threatening event.
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Dietary omega-3 fatty acids for women
Biomedicine & PharmacotherapyVolume 61, Issues 2-3February-April 2007Pages 105-112
Jean-Marie Bourre
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Levels of dioxins, dibenzofurans, PCB and DDE congeners in pooled food samples collected in 1995 at supermarkets across the United States
ChemosphereVolume 34, Issues 5-7March-April 1997Pages 1437-1447
Arnold Schecter, Paul Cramer, Kathy Boggess, John Stanley, James R. Olson

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